The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.
Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.
The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.
Immune 8: Staying warm with γδ T cells
- May 25, 2018
- Tagged as: homeostasis, IL-17A, immune, immunology, T cells, thermogenesis, γδT cells
The Immune team reveals how γδT cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
Immune 7: Contradictory complements in Alzheimer’s Disease
- April 18, 2018
- Tagged as: AD, Alzheimer's disease, C1q, complement, immune, immunology, MAC, mouse model, synapse, synaptic pruning
The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer’s disease.
The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.
The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring.
The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.
Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.
Immune 2: Lymphocytes after dark
- November 25, 2017
- Tagged as: 24 hour clock, adaptive immunity, B cell, circadian, clock gene, immune, immunology, lymph, lymph node, lymphocyte, T cell
Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph is circadian – it is dependent on the time of day.
