TWiV reviews RFK Jr’s demand to revoke polio vaccine, Wuhan lab samples do not include close relatives to SARS-CoV-2, using artificial intelligence to discover the RNA virosphere, and biomarkers that discriminate early and late phases of respiratory virus infections from a SARS-CoV-2 human challenge study.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episode
- Support science education at MicrobeTV
- ASV 2025
- RFK Jr lawyer wants revocation of polio vaccine (CNN)
- Wuhan lab has no samples close to SARS-CoV-2 (Nature)
- Using AI to discover RNA virosphere (Cell)
- SARS-CoV-2 human challenge reveals biomarkers (Nat Comm)
- Does this challenge study pass the smell test? (TWiV 863)
- Letters read on TWiV 1179
- Timestamps by Jolene. Thanks!
Weekly Picks
Angela – Science’s 2024 breakthrough of the year, Lenacapavir “the long shot”. NEJM papers with Lenacapavir trials: one and two.
Kathy – Bach Toccatta and Fugue on floor piano
Rich – Never Cry Wolf
Vincent – Common Raven and American Crow
Listener Pick
Jaan – Meute (one, two, three)
Intro music is by Ronald Jenkees
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The post TWiV 1179: Dark matter and warning signs first appeared on This Week in Virology.
In response to a question “Could the diabetes epidemic be
caused by a virus, or is that just lazy thinking?” The following thought
occurred. Several examples such as Coxsackie
and Adenovirus are known for their interactions. Adv36, more known for its link
to obesity can serve as proof of concept. Adv36 has potential effects in enhancing
differentiation of preadipocytes. The mechanism
was traced to viral RNA expression pattern by M Rathod etal. Another paper by Wang etal demonstrated
adv36 infectionincreases glucose uptake in cells via Ras-activated PI
3-kinase pathway in an insulin-independent manner. Of
course, conditions such as obesity, diabetes or obesity have to be considered
under environmental and genetic influence also. Antiviral is not advocated for
diabetes or obesity.
I had blogged about it earlier. http://varuncnmicro.blogspot.in/2012/10/adenovirus-36-said-you-are-obese.html