TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research.
Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel
Guests: Stephanie Gras and Jenna Guthmiller
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Download TWiV 1169 (78 MB .mp3, 54 min)
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Links for this episode
- Goldilocks zone of influenza immunity (J Inf Dis)
- Broadly neutralizing HA antibodies (Nature)
- T cell epitopes needed for influenza vaccines (Clin Transl Immunol)
- T cell epitopes conserved in emerging H5N1 viruses (Clin Transl Immunol)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
The post TWiV 1169: Can anyone hook me up with a duck? first appeared on This Week in Virology.
I was thinking of Dr. Racaniello dealing with his flooded house while watching this BBC film about the storm and the effect of social media, “Superstorm Sandy: Caught on Camera”, http://www.hulu.com/watch/427229
Vincent,
A new twist is using spider silk and its long polymer chains by incorporating the amino acids Arg-Gly-Asp (RGD) within the protein, RGD enables stem cells to “latch on” using integrin receptors..in theory (and ultimate goal) is to create stem cells that elongate without differentiating so that one day spinal cord victims can be implanted with their own cells and “bridge” the break enabling repair.
Spider silk link:
http://www.ncbi.nlm.nih.gov/pubmed/22727466
One of many virus engineered RGD motifs engineered for multi-valent display to interact with stem cells (yes plugging one of my papers 🙂
http://www.ncbi.nlm.nih.gov/pubmed/22522012
RGD within M13 virus particle, by Dr. Seung-Wuk Lee from Berkeley, considered the pioneer guy in the field.
http://pubs.acs.org/doi/abs/10.1021/la100226u
While I’ve moved on to influenza for my postdoc I have a soft spot in my heart for exploiting viruses and proteins for new uses (virus batteries, nanowires, etc.)
Hope the house is dried out and listened with enthusiasm about the spider-silk story while on my Sunday run.
Josh Powell
Maybe the authors of the silk stabilization paper didn’t do plaque assays of the MMR vaccine because they had three different viruses in the assay? RT-qPCR would be easier to multiplex in this case I would have thought.
Very interesting program, would be nice if discussion is focused on the topic.