TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episode
- MicrobeTV Discord Server
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- Novel H5N1 in Cambodia (medRxiv)
- More cVDVP2 circulation (polioeradication.org)
- Infectious parvovirus B19 with proteases (Nat Comm)
- B cell receptor enhancement of dengue disease (PLoS Path)
- Timestamps by Jolene. Thanks!
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The post TWiV 1167: Virus cloak and entry first appeared on This Week in Virology.
I’ve been looking at the genome sequences of Enterovirus-71 (EV-71). Plenty of them are available on NCBI, most from Chinese outbreaks. It’s an impressive virus and so many strains are out there, likely makes a vaccine problematic. There is a nice mouse-adapted strain of EV-71 and a few infectious clones reported in the literature. Vincent, you bring up good points about EV-71, it may be more informative to look at the genomes of the host children. Finally, just like H5N1 we only hear about the cases that end up in the emergency room. I hope the press doesn’t start saying the virus kills 80% of the people it infects 🙂
Does anyone have a good reference that gets at the infection control doc’s email concerning the different modes of transmission for different pathogens? I would love to throw some data for some different pathogens at my allied health micro class for them to interpret… I know its out there but it I am stymied every time I search pubmed for something so broad.