TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Download TWiV 1167 (62 MB .mp3, 103 min)
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- Novel H5N1 in Cambodia (medRxiv) 6:28
- More cVDVP2 circulation (polioeradication.org) 11:48
- Infectious parvovirus B19 with proteases (Nat Comm) 12:16
- B cell receptor enhancement of dengue disease (PLoS Path) 42:31
- Letters read on TWiV 1167 1:00:53
- Timestamps by Jolene. Thanks!
Weekly Picks 1:28:20
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Kathy – 450 Million year old arthropods preserved in fool’s gold. Primary article Pyrite video
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Listener Picks
Jack – Coronavirus vaccine update
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
The post TWiV 1167: Virus cloak and entry first appeared on This Week in Virology.
It was great to see Ken discuss this extreme virus research with great enthusiasm. With all the human virus talk these days its nice to switch gears and talk about this. I still scratch my head at how a tombusvirus icosahedral capsid (closely realted to the TBSV plant virus capsid) could package a DNA instead of RNA genome such as this and be stable at pH 3.0 at elevated temperatures. TBSV is considered a “weak” virus with critical cation-stable cites required just to be stable. These cation sites are also apparently conserved within this virus.
With all that aside…I’m excited to see how this story unfolds. I would also love to see Ken bring his enthusiasm and be a contributor to your show 2 or 3 times a year. He fits perfectly with you guys and its nice to mix it up with this type of virology 🙂