TWiV 1154: Clinical update with Dr. Daniel Griffin

October 4, 2024

In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume.

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Links for this episode

Rwanda: Marburg virus disease (WHO)

Passport required?…..Marburg virus commutes to Germany (CIDRAP)

Outbreak of whooping cough/pertussis…..no lifelong immunity following vaccination? (Bloomberg

Protection of infants by maternal antibodies against RSV by either vaccination or nirsevimab (MMWR)

WHO recommendations for RSV: maternal vaccination and antibody shot  (Reuters)

Ziresovir for RSV hospitalized infants (NEJM)

Crawling to effective anti-RSV countermeasures (NEJM)

The $800 million pledge for African mpox response (Reuters)

COVID-19 deaths (CDC)

COVID-19 national and regional trends (CDC)

Waste water scan for 11 pathogens (WastewaterSCan)

COVID-19 variant tracker (CDC)

SARS-CoV-2 genomes galore (Nextstrain)

Doffing your PPE– contact precautions (CID)

mRNA vaccination does not elicit durable immune response (Nature Medicine)

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)

Where to get pemgarda (Pemgarda)

EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)

CDC Quarantine guidelines (CDC)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

What to do when sick with a respiratory virus (CDC)

When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Mechanisms of long COVID and therapeutics (Cell)

Post hospitalization cognitive deficits and grey matter reduction 1 year after COVID-19 (Nature Medicine)

Letters read on TWiV 1154

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1154: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

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0 comments on “TWiV 1154: Clinical update with Dr. Daniel Griffin

  1. This is one of the top five twiv episodes ever. Please keep getting clinicians more often!

  2. This was an awesome episode. “Must” listening for anyone who has ever had a viral illness, ever had a kid with a high fever who they have rushed to the hospital, or who is just plain enjoys eavesdropping on a cool conversation between physicians and scientists who study the same phenomena in different ways. Thanks to all the TWiV “hosts” for another pleasurable and fascinating 90 minutes!

  3. $5278445 May 31, 2011

    It’s pronounced: Cook-sock-ee.  It’s not whatever you were saying…that frankly sounded a bit kinky!

    • Are you sure about that pronunciation of Coxsackie? I’ve been saying
      it the other way for 30 years, as has every other virologist I’ve
      known.

      • $5278445 Jun 1, 2011

        Hmm, interesting. But I’m from that region. In fact, I was just at the high school not long ago. The only time I’ve heard Coxsackie pronounced the way you said it was when it was worked into a naughty quip that also included in the names of other local villages – Athens; Climax; and Freehold. I don’t remember how that one goes, but you get the picture…

        Here’s one random Youtube video of a person mentioning the village’s name several times. At time 3:21 is where it’s most clear:

        http://www.youtube.com/watch?v=g697-ZsP-O4

        {BTW: Time 3:14 includes an interesting historical tidbit.}

        Here’s another video in which the one commenter similarly corrects the village’s pronunciation:

        http://www.youtube.com/watch?v=FukWigO0Jjg

  4. malik Feb 8, 2012

    Hello..
    firstly i want to thank you for your great podcast.. i like it very much..
    i just want to make sure if Lyme disease is caused by Rickettsia or by Borrelia burgdorferi
    thanks again

    • Lyme disease is caused by the bacterium Borrelia burgdorferi which is a spirochaete.

      • malik Feb 8, 2012

        Thanks very much for reply.
        I just wanted to make correction because Dr Sacchetti mentioned that at 1:02:55 of the episode.
        I really appreciate your great efforts so thanks again