TWiV 1134: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.

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Links for this episode

Clesrovimab, RSV preventative monoclonal antibody for infants (Merck)

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine)

Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine)

NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID)

Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID)

Pemgarda infusion center locator (Pemgarda)

Respiratory virus guidance (CDC)

Early phase of SARS-CoV-2 infection (COVID.gov)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging)

Contribute to our Floating Doctors fundraiser

Letters read on TWiV 1134

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1134: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.