Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago.
The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and the association of a fungal RNA virus with white-nose syndrome of North American bats.
The TWiVestigators wrap up 2016 with a discussion of the year’s ten compelling virology stories.
The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.
The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.
The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus.
The TWiVsters describe a mouse model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the murine gene encoding an ortholog of the virus receptor.
Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, on his career and his work on HIV vaccines.
The multi-dimensional TWiV-brane brings you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!).
Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.