The TWiVniks review the past week’s findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans.
The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes.
The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.
Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.
Vincent, Philip, David, and Priscilla recorded this episode before an audience at the Harvard Virology Program Annual Retreat, where they discussed negative strand RNA viruses, a vaccine against herpes simplex virus type 2, lipidomics of viral infection, and science communication.
Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.
Vincent and Dick continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.
Vincent, Dick, and Alan converse about hantavirus spread by large deer mice, why the 1918 influenza virus replicates in the lower respiratory tract, measles in Europe, and the growing resistance of influenza virus to antivirals.