The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.

Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World.

Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa.