Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.
The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.
Vincent and Dick recall the discovery of Lassa virus in Africa in 1969. A non-fictional account of the story, ‘Fever’, written by John G. Fuller and published in 1974, inspired Vincent to become a virologist. Part of the story took place at Columbia-Presbyterian Hospital (now Columbia University Medical Center), where both Vincent and Dick are employed. Dick remembers many of the key players in this medical drama.