Amyloid plaquesThe TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Brianne Barker

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Weekly Science Picks 1:17:24

Brianne – Pandemic (board game)
Alan – The Shortwave Radio Audio Archive (site and blog)
Rich – James Cook’s First Pacific Voyage, 1768-1771 (interactive map)
DicksonThe Scientist on Instagram
Vincent – State of the World’s Fungi

Listener Pick

DavidBruno LaTour

Intro music is by Ronald Jenkees.

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hershey virus

Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.

Host: Vincent Racaniello

Guests: Nicholas Buchkovich and Leslie Parent

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Download TWiV 518 (53 MB .mp3, 86 min)
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Intro music is by Ronald Jenkees.

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Epomophorus wahlbergiBrianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.

Hosts: Vincent Racaniello and Brianne Barker

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Download TWiV 517 (48 MB .mp3, 79 min)
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Weekly Science Picks 1:07:03

Brianne – Ed Yong on AFM
Vincent – Goggles Optional podcast (especially #243)

Intro music is by Ronald Jenkees.

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HUSHLonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

Hosts: Vincent Racaniello, Dickson DespommierRich ConditKathy Spindler, and Brianne Barker

Guests: Leonid Yorkovetskiy and Jeremy Luban

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Download TWiV 516 (73 MB .mp3, 121 min)
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Weekly Science Picks 1:44:39

Brianne – The Chimp and the River by David Quammen
Rich – James Cook’s First Voyage Journal (20 sec Google Earth summary)
KathyHigh resolution Antarctica map NYTimes 46MB Maps  (more info and 43 tb maps)
DicksonJellyfish
Jeremy – Pictorial Guide to Living Primates; All The World’s Primates
Lonya – Chougui et al. HIV-2/SIV Vpx counters HUSH
Vincent – Research!America

Intro music is by Ronald Jenkees.

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Art by AnjeThe TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditKathy Spindler, and Brianne Barker

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Weekly Science Picks 1:19:56

Brianne – Germ City-Microbes and the Metropolis Museum Exhibition
Alan
Nikon 2018 Small World in Motion competition
KathyIon Torrent Sequencing (video)
Dickson2018 Nobel Prizes Economics
Kathy – Ocean-centric map
Vincent – Intelligence Matters Podcast: Anthony Fauci on threats from epidemics

Listener Picks

Gonsalo – Cells at Work (Manga, Anime)

Intro music is by Ronald Jenkees.

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mitochondrionThe TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Weekly Science Picks 1:29:35

AlanCompound Interest chemistry graphics
KathyWriting letters of recommendation Guidelines Trix & Psenka Schmader et al. Madera et al.
DicksonJapan Fireworks
Vincent – The Game of T-Cells and Apple Park Lego

Listener Picks

Steve – Shomu’s Biology

Intro music is by Ronald Jenkees.

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From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.

Host: Vincent Racaniello

Guest: Harry Greenberg

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Intro music is by Ronald Jenkees.

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potyvirus and geminivirusAnne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditBrianne Barker, and Anne Simon

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Download TWiV 512 (62 MB .mp3, 103 min)
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Weekly Science Picks 1:28:33

Brianne –  Why are so many genes unstudied? (Zimmer and Yong)
AlanUnveiling the RNA World
RichSpaghetti mystery solved (PNAS paper)
DicksonScience Fair
Vincent – A PhD Lab Coat Ceremony

Listener Picks

StephenFlu vaccine myth rant by Crislip
Jolene – Research Matters in PLoS Path and PLoS Biology
NicholasCharity Matters app

Intro music is by Ronald Jenkees.

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Ned LandauNed Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ned Landau

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Download TWiV 511 (66 MB .mp3, 109 min)
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Weekly Science Picks 1:31:20

BrianneOnline Immunology Course
AlanBacteria Builder
Rich – 2018 Ig Nobel Prizes
DicksonBetween Fear and Hope
Ned – HUSH silencing of transposons
Vincent – Paywall publishing ban (Schlitz statement); Curry on DORA

Listener Pick

StevePaywall: Business of Scholarship and Biohazard
IslamPeer review Twitter post

Intro music is by Ronald Jenkees.

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Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.

Hosts: Vincent Racaniello and Dickson Despommier

Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata

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Download TWiV 510 (39 MB .mp3, 64 min)
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Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv