David TullerDavid Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Hosts: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees.

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Phil SharpVincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.

Hosts: Vincent Racaniello

Guest: Phillip A. Sharp

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This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

neural circuit tracingThe TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Brianne Barker

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Download TWiV 461 (79 MB .mp3, 127 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy –Best eclipse video (to date) and solargraph
DicksonPhotos by Will Eades
BriannePale Rider by Laura Spinney
Rich – “Supergenes” Drive Evolution
Vincent –Anatomy of a Moral Panic

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.

Host: Vincent Racaniello

Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss

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Download TWiV 460 (56 MB .mp3, 93 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Saturn's virusThe TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 459 (63 MB .mp3, 105 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy – Cassini photos
DicksonCaliber Biotherapeutics
AlanGrav
RichGoogle street view of the International Space Station.  (article)
Vincent – the bioinformatics chat

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

subgenomic flavivirus RNAThe TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 458 (72 MB .mp3, 119 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy – Antibody validation Editorial Asilomar meeting report
DicksonDespommierphotoart.com
AlanNOAA Hurricane Hunters
Rich – Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent – Goodnight Lab by Chris Ferrie

Listener Picks

Pete – Change Agent by Daniel Suarez
Paul
Pasteur’s Gambit by Stephen Dando-Collins
Maureen – Discovery Documentary First in Human

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Rabbits_MyxomatosisTrial_WardangIsland_1938-300x250.jpgBrianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Brianne Barker

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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne – 3D printed viruses
DicksonSecrets of Schooling
Alan – Making sails in the Nevada desert
Rich – David Vetter isolation suit  (Wiki)
Vincent – Confounds the Science

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

dengue-cGASBrianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

Hosts: Vincent Racaniello and Rich Condit

Guest: Brianne Barker

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Download TWiV 456 (75 MB .mp3, 124 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne – Up-Goer Five Challenge (related to Thing Explainer)
Rich – The Farthest: Voyager in Space and Vipassana Momma: Science
Vincent – Episode of Revisionist History: The Basement Tapes

Listener Pick

Jennie – What Piece of Lab Equipment Are You?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

DNA encoded exploitErin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

Guest: Erin Garcia

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Download TWiV 455 (64 MB .mp3, 105 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Erin – What If? by Randall Monroe
Rich – Art.Science.Gallery (J. Haley Gillespie)
Kathy –
Astronomy photographer of the year shortlist
Alan – Upcoming Eclipses
Vincent – Ford Thunderbird Automatic Transmission Rebuild

Listener Pick

Bryan – Neuroscientists tricks journals

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Sharon Isern and Scott Michael

Sharon Isern and Scott Michael. Photo by Melissa Neubek.

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guests: Sharon Isern and Scott Michael

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Weekly Science Picks

Dickson – Industrial Scars
Kathy – Eclipse info by zipcode

Sharon – Michaela’s article in The Conversation
Scott – Signal P, PecaanPhameratorDNAmaster
Alan – The Eagle Whisperer (and the Great Big Story channel)
Vincent – Bottle

Listener Pick

Kevin – Tenure track scientist bites the dust

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv