Art by AnjeThe TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditKathy Spindler, and Brianne Barker

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Weekly Science Picks 1:19:56

Brianne – Germ City-Microbes and the Metropolis Museum Exhibition
Alan
Nikon 2018 Small World in Motion competition
KathyIon Torrent Sequencing (video)
Dickson2018 Nobel Prizes Economics
Kathy – Ocean-centric map
Vincent – Intelligence Matters Podcast: Anthony Fauci on threats from epidemics

Listener Picks

Gonsalo – Cells at Work (Manga, Anime)

Intro music is by Ronald Jenkees.

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mitochondrionThe TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Weekly Science Picks 1:29:35

AlanCompound Interest chemistry graphics
KathyWriting letters of recommendation Guidelines Trix & Psenka Schmader et al. Madera et al.
DicksonJapan Fireworks
Vincent – The Game of T-Cells and Apple Park Lego

Listener Picks

Steve – Shomu’s Biology

Intro music is by Ronald Jenkees.

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From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.

Host: Vincent Racaniello

Guest: Harry Greenberg

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Intro music is by Ronald Jenkees.

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potyvirus and geminivirusAnne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditBrianne Barker, and Anne Simon

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Weekly Science Picks 1:28:33

Brianne –  Why are so many genes unstudied? (Zimmer and Yong)
AlanUnveiling the RNA World
RichSpaghetti mystery solved (PNAS paper)
DicksonScience Fair
Vincent – A PhD Lab Coat Ceremony

Listener Picks

StephenFlu vaccine myth rant by Crislip
Jolene – Research Matters in PLoS Path and PLoS Biology
NicholasCharity Matters app

Intro music is by Ronald Jenkees.

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Ned LandauNed Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ned Landau

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Weekly Science Picks 1:31:20

BrianneOnline Immunology Course
AlanBacteria Builder
Rich – 2018 Ig Nobel Prizes
DicksonBetween Fear and Hope
Ned – HUSH silencing of transposons
Vincent – Paywall publishing ban (Schlitz statement); Curry on DORA

Listener Pick

StevePaywall: Business of Scholarship and Biohazard
IslamPeer review Twitter post

Intro music is by Ronald Jenkees.

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Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.

Hosts: Vincent Racaniello and Dickson Despommier

Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata

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Intro music is by Ronald Jenkees.

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planarianThe TWiV team considers whether those who can do, can’t teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveKathy Spindler and Brianne Barker

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Weekly Science Picks 1:29:11

Brianne – Climate change visualization
Alan – Anova sous vide cooker
DicksonFire season in western US
KathySunscreen in UV and The Projector Illusion
Vincent – The Usefulness of Useless Knowledge

Listener Pick

RiverThe Conscience of the Present

Intro music is by Ronald Jenkees.

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Soviet Bioweapons FacilitiesJens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector.

Hosts: Vincent Racaniello, Dickson DespommierRich Condit, and Kathy Spindler

Guest: Jens Kuhn

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Weekly Science Picks 1:49:12

Jens – Nudibranchs, Beastly Garden, large nidovirus (one, two)
Rich –Living inside a canister
Dickson –
Global rivers and streams
Kathy – TWiM 181 Dr. Warhol’s Periodic Table of Microbes
Vincent – Twitter Bots and Russian Trolls Amplify Vaccine Debate

Intro music is by Ronald Jenkees.

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vaccinia virus proteinsThe TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks 1:38:52

Alan – Puzzled Escape Games
Rich – An Extremely Detailed Map of the 2016 Election
Dickson – Parker Solar Probe
Kathy – Ancient earth globe and connected Dinosaur database
Brianne
 – STEMM education should get HACD
Vincent – Free tuition for all NYU medical students

Listener Pick

HeatherGoFarm blog

Intro music is by Ronald Jenkees.

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David TullerDavid Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Host: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees.

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