John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: John Mascola

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Weekly Picks 1:33:57

Brianne How Sesame Street is Handling the Pandemic
RichZamboni: How it works
AlanHow lightning starts
Vincent Buon-A-Petitti

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MeikaWordle

Intro music is by Ronald Jenkees

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Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Weekly Picks 1:22:00, 1:26:16

JonThe Premonition by Michael Lewis
DicksonNature photographer of the year 2021
Brianne Should BioBank Volunteers Be Warned About Mutations?
RichCzech singer Hanka Horká dies after intentionally getting infected by the coronavirus and Dena Dietrich Dies at 91
Vincent Cuore di Cioccolato

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BronwenSchools must stay open
JohnPandemic humor

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In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic.

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Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Alessandro Sette

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  • Travel Award Applications (ASV) 1:01:36
  • Impact of variants on T cells (Cell Rep Med) 16:38
  • Timestamps by Jolene. Thanks!
  • Letters read on TWiV 855 1:07:43

Weekly Picks 1:18:00

Brianne75 years of research on human diseases in 1 minute
Kathy10 second video of COVID-19 spread
RichDiffraction spike
Vincent John’s Furniture Repair and Transcend Furniture Gallery

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AlisonFDA drug shortages
IngridOne woman’s mission to get vaccines to her rural Alabama town

Intro music is by Ronald Jenkees

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TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:40:03

DicksonFavorite Science Photos of 2021
BrianneViruses, Vaccines, and COVID-19 videos from American Museum of Natural History
KathyKlompas et al. “Current insights into respiratory virus transmission…”
RichLeviathan Falls by James S.A. Corey
Vincent Ebola (1996) by David Molesky at The Incubator

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RandallRobert Malone & Peter McCullough: A litany of untruths
SuellenOmicron and the case of the hidden evolution – Understanding Evolution

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In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis.

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Intro music is by Ronald Jenkees

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A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Download TWiV 852 (63 MB .mp3, 104 min)
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Weekly Picks 1:23:43

BrianneEvery Pore on Your Face Is a Walled Garden
Rich“On Warts” by Lewis Thomas (Pdf)
Vincent Cells at Work Code Black 1

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ChrisRia Lina on the Guilty Feminist podcast
DuncanMeet the green kleptos of the animal kingdom

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The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld

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Download TWiV 851 (61 MB .mp3, 102 min)
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Weekly Picks 1:26:51

DicksonEngineering the James Webb Space Telescope
Amy T cells might be our bodies’ best shot against Omicron
BrianneWhere is Webb?
RichFirst U.S. vaccine mandate in 1809 launched 200 years of court battles
Vincent The Secret of Life by Howard Markel

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JenAntidote
DavidRosie Revere, Engineer

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In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID.

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Intro music is by Ronald Jenkees

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TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 849 (61 MB .mp3, 102 min)
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Weekly Picks 1:47:58

Brianne Don’t Look Up
Kathyspaceweather.com
RichVideo of a Green Flash  (wiki)
Alan Fungally-modified violins
Vincent This Old Tony especially this segment

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PaulDeep Mind and AlphaFold
GrantSARS-CoV-2 reproduction cycle

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