This Week in Virology

TWiV 524: Slicing and dicing with Raul

December 12, 2018

Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.

Hosts: Vincent Racaniello and Amy Rosenfeld

Guest: Raul Andino

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Links for this episode

TWiV 138: RISCy business with Raul Andino 1:26
TWiV 33: Live in Philly 1:11
Viral protein restricts insect immunity (Cell Host Micr) 15:21, 27:14
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:06:28

Amy – Insectropolis
Vincent – Genome-edited baby

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 523: Virology in Zürich

December 9, 2018

At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.

Hosts: Vincent Racaniello

Guests: Cornel Fraefel, Urs Greber, and Silke Stertz

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Links for this episode

AAV2 and HSV1 co-infections (J Virol) 19:36
Movies of HeLa Fucci cells (J Virol) 19:55
Cathepsin W and influenza virus entry (mBio) 37:28
Plaque 2.0 (PLoS One) 1:01:49
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 522: Readers of the lost ORF

December 2, 2018

The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Links for this episode

Genome-edited babies (Nature) 6:25
Second CRISPR pregnancy? (MIT Tech Rev) 17:34
Naturally occurring DNA virus of Drosophila (PLoS Path) 24:47
Upstream protein coding region in enterovirus genome (Nat Micro) 50:58
We missed it in 1988! (J Virol) 1:11:36
Letters read on TWiV 522 20:46, 1:18:39
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:32:20

Alan – $40 internationally standard cup of tea
Rich – Mars InSight Mission
Dickson – New York Botanical Garden Train Show (his photos here)
Kathy – Comedy wildlife photo awards finalists
Vincent – Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research

Listener Pick

Fernando – Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 521: Spitting in the Allee

November 25, 2018

Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai 3:00
30,000 year old Mollivirus sibericum (PNAS) 21:00
Aggregating viruses promotes early replication (Curr Biol) 57:13
Letters read on TWiV 521 4:29
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:28:08

Brianne – Why don’t we have vaccines against everything?
Rich – Golden Globe Race
Dickson – The Anatomy of Figure Drawing by Robert Demarest and Warder Clyde Allee
Kathy – Orientation of the moon’s appearance, Southern Hemisphere
Vincent – Paul has Measles in English and Spanish

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 520: This old mouse

November 18, 2018

The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai 4:47
MSc program Molecular Biology and Pathology of Viruses, Univ College London 6:04
Virology Comics on sale (Amazon) 7:15
Outbreak at the Smithsonian 19:53
NIAID strategic plan for universal influenza vaccine 22:39
Fauci article on universal influenza vaccine (J Inf Dis) 22:51
Severe 2017-18 flu season (CDC) 24:04
Progress on universal influenza vaccine (The Scientist) 25:51
Influenza vaccine is safe for those with egg allergies (virology blog) 38:01
Atypical parvovirus drives mouse kidney disease (Cell) 51:16
Contagious Thinking: Visible Viruses AR app 1:31:15
Letters read on TWiV 520 10:10, 51:18, 1:24:25
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:32:54

Brianne – Nebula Genomics: a new start-up offering free genome sequencing (with a catch)
Alan – GRE scores are poor predictor of degree completion
Rich – The Science Mill (video)
Dickson – The 12 cranial nerves (mnemonic)
Kathy – NAS report on Sexual Harassment of Women (free pdf) Iceberg figure
Vincent – The Tangled Tree by David Quammen and TWiEVO #37

Listener Pick

Mark – Weekly US Map: Influenza Summary

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 519: Fishing for viruses in senile

November 11, 2018

The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Download TWiV 519 (58 MB .mp3, 96 min)
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Weekly Science Picks 1:17:24

Brianne – Pandemic (board game)
Alan – The Shortwave Radio Audio Archive (site and blog)
Rich – James Cook’s First Pacific Voyage, 1768-1771 (interactive map)
Dickson – The Scientist on Instagram
Vincent – State of the World’s Fungi

Listener Pick

David – Bruno LaTour

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 518: Hershey’s viruses

November 4, 2018

Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.

Host: Vincent Racaniello

Guests: Nicholas Buchkovich and Leslie Parent

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Download TWiV 518 (53 MB .mp3, 86 min)
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Links for this episode

HIV-1 gag membrane binding domain (J Virol) 16:54
Nuclear experience for gag (PNAS) 24:13
Gag in nucleolus (J Virol) 31:30
YB-1 for retrovirus assembly (J Virol) 33:02
HCMV controls BiP levels (J Virol) 42:13
HCMV regulates La (J Virol) 47:30
Inhibition of HCMV by modulating syntaxin 5 (J Virol) 1:03:02
Non-envelopment role for ESCRT-III during HCMV infection (J Virol) 1:07:22
Late retroviral budding function (J Virol) 55:56
Grit by Angela Duckworth 1:20:18
The Scientists by John Gribbin 1:21:22
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 517: Just in time for Halloween

October 28, 2018

Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.

Hosts: Vincent Racaniello and Brianne Barker

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Download TWiV 517 (48 MB .mp3, 79 min)
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Links for this episode

Pan American Society for Clinical Virology San Diego and Houston Regional Meetings 2:13
It’s not SARS 2.0 (TWiV 364) 6:45
Bats out of hell (TWiV 183) 7:19
Bombali virus, a new Ebolavirus (Nat Micro) 9:15
Asymptomatic Ebolavirus infections (virology blog) 25:26
Bat-borne mumps virus (Cell Rep) 27:43
Image credit
Letters read on TWiV 517 1:03:46
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:07:03

Brianne – Ed Yong on AFM
Vincent – Goggles Optional podcast (especially #243)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 516: HUSH little virus, don’t you transcribe

October 21, 2018

Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Leonid Yorkovetskiy and Jeremy Luban

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Download TWiV 516 (73 MB .mp3, 121 min)
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Links for this episode

Pan American Society for Clinical Virology San Diego and Houston Regional Meetings 4:22
Vpr and Vpx counter HUSH (Nat Micro) 8:34, 56:46
Vpr and Vpx counter HUSH (bioRxiv version)
Schematic of HUSH complex (Lehner lab) 1:08:17
Olive colobus monkey sound credit 1:53:14
Image credit: William (Ted) Diehl
Letters read on TWiV 516 5:07
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:44:39

Brianne – The Chimp and the River by David Quammen
Rich – James Cook’s First Voyage Journal (20 sec Google Earth summary)
Kathy – High resolution Antarctica map NYTimes 46MB Maps (more info and 43 tb maps)
Dickson – Jellyfish
Jeremy – Pictorial Guide to Living Primates; All The World’s Primates
Lonya – Chougui et al. HIV-2/SIV Vpx counters HUSH
Vincent – Research!America

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 515: When virus is in retrograde

October 14, 2018

The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Download TWiV 515 (60 MB .mp3, 99 min)
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Links for this episode

Sea Phages program and application materials 3:42
Tom Steitz, 78 (NY Times) 4:47
AFM outbreak, US (CIDRAP) 12:23
AFM surveillance (CDC) 11:28
Acute Flaccid Paralysis and Enteroviral Infections (Curr Inf Dis Rep) 13:08
EV-D68 neurotropism (bioRxiv) 15:46
Ebola virus outbreak continues in DRC (CIDRAP) 17:03
Vaccinia virus respiratory infection (Int J Inf Dis) 21:36
HPV L2 penetrates endosome, brings virus retro (Cell) 38:38
Letters read on TWiV 515 10:53, 1:18:44
Art by Anje Claeys
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:19:56

Brianne – Germ City-Microbes and the Metropolis Museum Exhibition
Alan – Nikon 2018 Small World in Motion competition
Kathy – Ion Torrent Sequencing (video)
Dickson – 2018 Nobel Prizes Economics
Kathy – Ocean-centric map
Vincent – Intelligence Matters Podcast: Anthony Fauci on threats from epidemics

Listener Picks

Gonsalo – Cells at Work (Manga, Anime)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 524: Slicing and dicing with Raul

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Weekly Science Picks 1:06:28

TWiV 523: Virology in Zürich

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TWiV 522: Readers of the lost ORF

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Weekly Science Picks 1:32:20

Listener Pick

TWiV 521: Spitting in the Allee

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Weekly Science Picks 1:28:08

TWiV 520: This old mouse

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Weekly Science Picks 1:32:54

Listener Pick

TWiV 519: Fishing for viruses in senile

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Weekly Science Picks 1:17:24

Listener Pick

TWiV 518: Hershey’s viruses

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TWiV 517: Just in time for Halloween

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Weekly Science Picks 1:07:03

TWiV 516: HUSH little virus, don’t you transcribe

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TWiV 515: When virus is in retrograde

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