Raul and VincentRaul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.

Hosts: Vincent Racaniello and Amy Rosenfeld

Guest: Raul Andino

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Weekly Science Picks 1:06:28

Amy – Insectropolis
Vincent – Genome-edited baby

Intro music is by Ronald Jenkees.

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At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.

Hosts: Vincent Racaniello

Guests: Cornel Fraefel, Urs Greber, and Silke Stertz

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Intro music is by Ronald Jenkees.

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readers-of-the-lost-ORFThe TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Weekly Science Picks 1:32:20

Alan – $40 internationally standard cup of tea
RichMars InSight Mission
DicksonNew York Botanical Garden Train Show (his photos here)
Kathy – Comedy wildlife photo awards finalists
Vincent – Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research

Listener Pick

Fernando – Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin

Intro music is by Ronald Jenkees.

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Pablo tiene sarampiónTeam TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

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Weekly Science Picks 1:28:08

Brianne – Why don’t we have vaccines against everything?
Rich – Golden Globe Race
DicksonThe Anatomy of Figure Drawing by Robert Demarest and Warder Clyde Allee
Kathy – Orientation of the moon’s appearance, Southern Hemisphere
Vincent – Paul has Measles in English and Spanish

Intro music is by Ronald Jenkees.

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science emojiThe TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit,  Kathy Spindler, and Brianne Barker

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Weekly Science Picks 1:32:54

Brianne – Nebula Genomics: a new start-up offering free genome sequencing (with a catch)
Alan – GRE scores are poor predictor of degree completion
Rich – The Science Mill (video)
DicksonThe 12 cranial nerves (mnemonic)
Kathy – NAS report on Sexual Harassment of Women (free pdf)  Iceberg figure
Vincent – The Tangled Tree by David Quammen and TWiEVO #37

Listener Pick

MarkWeekly US Map: Influenza Summary

Intro music is by Ronald Jenkees.

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Amyloid plaquesThe TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Brianne Barker

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Weekly Science Picks 1:17:24

Brianne – Pandemic (board game)
Alan – The Shortwave Radio Audio Archive (site and blog)
Rich – James Cook’s First Pacific Voyage, 1768-1771 (interactive map)
DicksonThe Scientist on Instagram
Vincent – State of the World’s Fungi

Listener Pick

DavidBruno LaTour

Intro music is by Ronald Jenkees.

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hershey virus

Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.

Host: Vincent Racaniello

Guests: Nicholas Buchkovich and Leslie Parent

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Download TWiV 518 (53 MB .mp3, 86 min)
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Intro music is by Ronald Jenkees.

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Epomophorus wahlbergiBrianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.

Hosts: Vincent Racaniello and Brianne Barker

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Weekly Science Picks 1:07:03

Brianne – Ed Yong on AFM
Vincent – Goggles Optional podcast (especially #243)

Intro music is by Ronald Jenkees.

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HUSHLonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

Hosts: Vincent Racaniello, Dickson DespommierRich ConditKathy Spindler, and Brianne Barker

Guests: Leonid Yorkovetskiy and Jeremy Luban

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Download TWiV 516 (73 MB .mp3, 121 min)
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Weekly Science Picks 1:44:39

Brianne – The Chimp and the River by David Quammen
Rich – James Cook’s First Voyage Journal (20 sec Google Earth summary)
KathyHigh resolution Antarctica map NYTimes 46MB Maps  (more info and 43 tb maps)
DicksonJellyfish
Jeremy – Pictorial Guide to Living Primates; All The World’s Primates
Lonya – Chougui et al. HIV-2/SIV Vpx counters HUSH
Vincent – Research!America

Intro music is by Ronald Jenkees.

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Art by AnjeThe TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditKathy Spindler, and Brianne Barker

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Download TWiV 515 (60 MB .mp3, 99 min)
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Weekly Science Picks 1:19:56

Brianne – Germ City-Microbes and the Metropolis Museum Exhibition
Alan
Nikon 2018 Small World in Motion competition
KathyIon Torrent Sequencing (video)
Dickson2018 Nobel Prizes Economics
Kathy – Ocean-centric map
Vincent – Intelligence Matters Podcast: Anthony Fauci on threats from epidemics

Listener Picks

Gonsalo – Cells at Work (Manga, Anime)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv