Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Eva Harris and Janet Smith

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Weekly Picks 1:44:07

AlanScience Photographer of the Year Awards
RichBar Keeper’s Friend
KathyPerseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission.
VincentCOVID-19 dataset

Listener Picks

MatthewRemembering the colleagues we lost to COVID-19
LoriIceberger

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guest: Ginger Campbell, MD

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Weekly Picks 1:34:15

DicksonSoapbox Gallery
BrianneCell Picture Show
RichPerseverance Rover’s Descent and Touchdown on Mars (Official NASA Video)
VincentOur World in Data (see COVID-19 vaccinations)

Intro music is by Ronald Jenkees

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The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:42:45

DicksonWhat is the polar vortex?
BrianneCloning of the black-footed ferret
Alan – Explaining mRNA vaccines with Star Wars
RichBrighton Collaboration (BRAVATO); Ad26 vector template
KathyTarget public health ads to zipcodes
VincentAnd Then the Gorillas Started Coughing

Listener Pick

Kim – Virus getting the shot (jpg)

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Paul Offit

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Weekly Picks 1:43:17

DicksonLife in a Day 2020
BrianneMicrocosms in Glass
AlanNEJM article on promoting vaccination, interview with lead author
RichThe Microbescope
VincentAutism’s False Prophets by Paul Offit

Listener Pick

EarlScience is Real Pins

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:38:56

BrianneDo scientists read enough fiction?
RichInsects in flight; Insect flight|Capturing takeoff
KathyBadger seal
VincentMicrobeTV merchandise

Intro music is by Ronald Jenkees

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Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guests: Paul Bieniasz and Theodora Hatziioannou

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Weekly Picks 1:46:30

DicksonMars Perseverance Rover
AlanThe Outlaw Ocean
RichAnand Varma Photography
VincentVirology Lectures 2021

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.

Hosts: Daniel Griffin and Vincent Racaniello

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Download TWiV 716 (31 MB .mp3, 52 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv