Saturn's virusThe TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 459 (63 MB .mp3, 105 min)
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This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy – Cassini photos
DicksonCaliber Biotherapeutics
AlanGrav
RichGoogle street view of the International Space Station.  (article)
Vincent – the bioinformatics chat

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

subgenomic flavivirus RNAThe TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 458 (72 MB .mp3, 119 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy – Antibody validation Editorial Asilomar meeting report
DicksonDespommierphotoart.com
AlanNOAA Hurricane Hunters
Rich – Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent – Goodnight Lab by Chris Ferrie

Listener Picks

Pete – Change Agent by Daniel Suarez
Paul
Pasteur’s Gambit by Stephen Dando-Collins
Maureen – Discovery Documentary First in Human

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Rabbits_MyxomatosisTrial_WardangIsland_1938-300x250.jpgBrianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Brianne Barker

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Download TWiV 457 (74 MB .mp3, 123 min)
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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne – 3D printed viruses
DicksonSecrets of Schooling
Alan – Making sails in the Nevada desert
Rich – David Vetter isolation suit  (Wiki)
Vincent – Confounds the Science

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

dengue-cGASBrianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

Hosts: Vincent Racaniello and Rich Condit

Guest: Brianne Barker

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Download TWiV 456 (75 MB .mp3, 124 min)
Subscribe (free): iTunesRSSemail

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne – Up-Goer Five Challenge (related to Thing Explainer)
Rich – The Farthest: Voyager in Space and Vipassana Momma: Science
Vincent – Episode of Revisionist History: The Basement Tapes

Listener Pick

Jennie – What Piece of Lab Equipment Are You?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

DNA encoded exploitErin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

Guest: Erin Garcia

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Download TWiV 455 (64 MB .mp3, 105 min)
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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Erin – What If? by Randall Monroe
Rich – Art.Science.Gallery (J. Haley Gillespie)
Kathy –
Astronomy photographer of the year shortlist
Alan – Upcoming Eclipses
Vincent – Ford Thunderbird Automatic Transmission Rebuild

Listener Pick

Bryan – Neuroscientists tricks journals

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Sharon Isern and Scott Michael

Sharon Isern and Scott Michael. Photo by Melissa Neubek.

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guests: Sharon Isern and Scott Michael

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Download TWiV 454 (65 MB .mp3, 108 min)
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Weekly Science Picks

Dickson – Industrial Scars
Kathy – Eclipse info by zipcode

Sharon – Michaela’s article in The Conversation
Scott – Signal P, PecaanPhameratorDNAmaster
Alan – The Eagle Whisperer (and the Great Big Story channel)
Vincent – Bottle

Listener Pick

Kevin – Tenure track scientist bites the dust

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Diane Griffin

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Download TWiV 453 (39 MB .mp3, 64 min)
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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Lynda CoughlanLynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Guest: Lynda Coughlan

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Download TWiV 452 (68 MB .mp3, 113 min)
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Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:33:45

Kathy – US rivers as subway map
Lynda – No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot
Alan
– Apollo-era computers found in dead engineer’s basement
Vincent – 110 NFL Brains, research article in JAMA and The best science is often accidental

Listener Pick

Stig – Security Now! and The Gene by Siddhartha Mukherjee
Ricardo – John Oliver on Vaccines

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

West Nile virus mosquitoesThe TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 451 (63 MB .mp3, 104 min)
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Links for this episode

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:29:45

Kathy – Approaching Jupiter and Michigan parents about vaccination
Rich – Math Limericks from Futility Closet
Alan
NASA flyover of Pluto
Vincent – Talk show host nominated as USDA chief scientist

Listener Pick

Neil – These smart girls are here to debunk anti-vaxxer nonsense
John – John Sever AMA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

no diceBen tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab’s finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Ben tenOever

Click arrow to play
Download TWiV 450 (58 MB .mp3, 96 min)
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Links for this episode

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:16:05

Ben – Invisible Invaders by Peter Radetsky
Kathy –
ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force
Rich – Columbia river gorge and Undaunted Courage by Stephen Ambrose
Dickson –
All the World’s Earthquakes
Alan
Map of Roman roads
Vincent – Brain atlas of fly behavior

Listener Pick

Rob – Vaccinate Your Kids and Charles Darwin Natural Selection
Islam – Self-assembling virus and Virus Patterns

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv