TWiM 206: Bacteria send nucleotide signals

October 4, 2019

The TWiM holobionts pay tribute to Stuart Levy, and reveal the remarkably diverse array of cyclic nucleotides synthesized by bacteria that likely mediate interactions with animal and plant hosts.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

Right click to download TWiM#206 (47 MB .mp3, 65 minutes)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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One comment on “TWiM 206: Bacteria send nucleotide signals

  1. Rich Bradley Oct 8, 2019

    Dear esteemed TWIM hosts, many thanks for another thought provoking episode.

    Your reference to cGAS/STING and interferon got me thinking somewhat tangentially about references to the presence of z-DNA stimulating interferon production and I would be interested in knowing if there is any accepted view of the role of z-DNA. z-DNA appears to have been initially thought of as a relic of using artificial conditions to determine DNA structure, but there now appears to be a school of thought that cells have adapted to recognise z-DNA (such as with Alu sequences – and possibly also viruses) leading to a cellular response and I would be interested in your thoughts. I did check Flint’s Virology but I couldn’t see any anti-viral z-DNA responses being covered.
    By the way I came across the reference “Z-DNA and Z-RNA in human disease” by Herbert in January’s edition of Nature Communications Biology where he discusses Alu.

    Many thanks, Rich

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