Stan Maloy writes:
Hi TWIM team —> We thoroughly enjoyed your visit to SDSU!
Thought you might enjoy this fun, short, insightful JMBE article by Elio on a graduate Integrative Microbiology course he’s been co-teaching.
In case you’d like to link it as a follow-up to his interview, the article is open access. —> Stanley
OMG just listened to the TWIM featuring a stroll down memory lane with Elio and it was AWESOME! He really is a remarkable person — and scientist. I loved his stories. Science needs more Elios!
What ?!?! Elio, you’re that Schaechter?
Elio is short for Moselio?
The back-to-back papers that you, Kjeldgaard, and Maaloe did in ’58 were so so so cool. I was really interested by the shift-up experiments because my dissertation was about mRNA regulation after an up-shift in yeast. Steady-state physiology at different growth rates is of course foundational to this process. I once heard someone say “systems biology is just physiology with marketing”, and I think that microbial physiology lives on inside the field of systems biology. Even now the field is working to describe the mechanisms of the “interia” of growth rate described by Arthur Henrici (back around when Elio was born, I estimate).
Elio, your 2015 review points towards Terrance Hwa’s group’s work modeling the balance of gene expression at different growth rates, and I figured I’d mention two other extensions of these ideas. Naama Barkai’s group has been doing awesome work in yeast, recently in 2016 Cell and 2017 Elife, examining the dynamic limitations of proteome allocation in different growth conditions and transitions. Great work. On the modeling front, Giordano et al in PLoS Comp. Biology 2016 demonstrates (in silico) an intriguing strategy to the problem of resuming growth rapidly – the bang bang singular.
Maybe the physiology of microbial growth would make for good TWiM?
Best of luck,
You may have already seen this 6/18/19 New York Times article on vaccination safety: Vaccine Injury Claims are Few and Far Between. Perhaps citing vaccination safety facts similar to these would be a good complement to your passion regarding the issue.
“Programmable bacteria induce durable tumor regression and systemic antitumor immunity” sounds like a very interesting paper. I wonder if you could review it on TWiM?
BTW, I’m not sure if it’s my exposure to your TWiM, TWiEVO and Immunology podcasts, or yours, but I really like the way you seem to be increasingly discussing the overlap between these fields. It’s great.
Mark in Missoula