Immune 9: Neither mice nor lamprey lie

June 20, 2018

Sea Lamrpey LarvaeThe Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Music by Steve Neal. Immune logo image by Blausen Medical.

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2 comments on “Immune 9: Neither mice nor lamprey lie

  1. Peter Foster Jul 2, 2018

    Dear Immune Team
    Listening to BBC Radio Five last week I heard mention of a rare immune system reaction that I was previously unaware of – the abscopal effect. This is a reaction when localised high dose radiotherapy is given to a cancer patient and results not only in remission at the radiotherapy site but also at metastatic sites throughout the body, sometimes resulting in complete remission.
    This has been known about since the 1950s but only recently has much progress been made in understanding the effect. The abscopal effect has been more frequently observed since the introduction of the immune checkpoint blocking antibodies Ipilimumab and pembrolizumab.
    I think the abscopal effect would be an interesting topic for discussion on Immune.
    I include links to some recent literature:
    https://www.nature.com/articles/nrc.2018.6
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346418/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828732/

  2. Greetings all,
    Episode 9 included a discussion of introductory books about immunology. I recently read The Immune System: A Very Short Introduction by Paul Klenerman (Oxford University Press). Since immunology is far from my field (computers and education) I like these short introductions because they don’t take a long time to read. I also enjoyed Viruses: A Very Short Introduction by Dorothy H. Crawford for the same reason. I haven’t read the microbiology one and it seems there isn’t one on parasites.

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