Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Alexander Dent

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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 34 (52 MB .mp3, 87 min)
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Music by Steve Neal.
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Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 33 (50 MB .mp3, 84 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 32 (54 MB .mp3, 91 min)
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Music by Steve Neal. Immune logo image by Blausen Medical

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Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 31 (55 MB .mp3, 90 min)
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Music by Steve Neal. Immune logo image by Blausen Medical.

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Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 30 (51 MB .mp3, 83 min)
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Music by Steve Neal. Immune logo image by Blausen Medical.

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Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Download Immune 29 (53 MB .mp3, 87 min)
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Music by Steve Neal. Immune logo image by Blausen Medical.

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Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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Music by Steve Neal. Immune logo image by Blausen Medical.

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Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks 1:22:07

Steph – Rotavirus & polio vaccines should be separated (article, paper)
CindyDiversify Immunology
VincentNo winter break from publish or perish

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv