This episode: Combining all 16 of yeast’s chromosomes into one or two only impairs their growth slightly in the lab, but it prevents them from successful mating with wild yeasts!
Download Episode (12 MB, 14 minutes)
Microbe of the episode: Vibrio succinogenes
Luo J, Sun X, Cormack BP, Boeke JD. 2018. Karyotype engineering by chromosome fusion leads to reproductive isolation in yeast. Nature 560:392–396.
Shao Y, Lu N, Wu Z, Cai C, Wang S, Zhang L-L, Zhou F, Xiao S, Liu L, Zeng X, Zheng H, Yang C, Zhao Z, Zhao G, Zhou J-Q, Xue X, Qin Z. 2018. Creating a functional single-chromosome yeast. Nature 560:331–335.
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